What is the goal blood glucose level in conventional insulin therapy for hyperglycemia in critically ill patients?

The goal blood glucose level in conventional insulin therapy for critically ill patients is set at 140-180 mg/dL. This target range is supported by evidence suggesting that maintaining blood glucose levels within this range can help reduce the risk of the complications associated with both hyperglycemia and hypoglycemia during critical illness.

Keeping glucose levels lower than 140 mg/dL may lead to increased risk of hypoglycemia, particularly in patients who are already fragile due to their critical condition. Aiming for levels above 180 mg/dL can lead to a greater risk of adverse outcomes, including increased morbidity. Therefore, the 140-180 mg/dL range strikes a balance, providing adequate control of hyperglycemia while minimizing the risk of hypoglycemic events. This approach is generally aligned with current guidelines for managing hyperglycemia in an intensive care environment, enabling more favorable patient outcomes.